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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)

AuthorsReferences (Sources)

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CD4+ CD25+ FOXP3 high Treg (peripherally induced)

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Contents

Origin: Periphery
Markers: CD4+, CD25 high, FoxP3 high, CD45RA-, CD45RO+, CD127 low HLA-DR -, CD95+, CTLA4+, Ki67+, ICOS+/-

Key features: Regulatory T Cells (Tregs) suppress T cell responses

What is generally the role of CD4+ CD25+ FOXP3 high Treg (peripherally induced)?

CD4+ Foxp3+ T Regulatory (Treg) cells are crucial for immune system balance and maintenance.
Buszko & Shevach 2020 Current Opinion in Immunology 67: 18-26

What can be achieved by altering the generation of Treg cells?

Modifying Treg cells' generation, stability, or function through drugs or biologics could treat autoimmune, inflammatory diseases, and cancers.
Buszko & Shevach 2020 Current Opinion in Immunology 67: 18-26

[CD4…

References (Sources)

A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn et al. 2013 Cell 155: 1282-1295
Control of regulatory T cell homeostasis
Buszko & Shevach 2020 Current Opinion in Immunology 67: 18-26
Review
Metabolic control of regulatory T cell development and function
Zeng & Chi 2015 Trends Immunol. 36: 3-12
Review
PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability
Hurrell et al. 2022 Nat Commun 13: 5118
Regulatory T cells in skin facilitate epithelial stem cell differentiation.
Ali et al. 2017 Cell 169: 1119-1129
Regulatory T cells: roles of T cell receptor for their development and function
Ohkura et al., 2010
Review
Role of NKT Cells in the Digestive System. II. NKT cells and diabetes
Wu & van Kaer, 2007

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