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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Ephrin receptors

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Ephrin receptors are among the largest family of Receptor tyrosine kinases (RTKs) (14 members in human). Based on their ligand-binding specifities, these receptors are grouped into two subclasses: EphA and EphB receptors
Frisén et al. 1999 Embo J. 18(19): 5159-5165
Wilkinson 2001 Nat Rev Neurosci 2: 156-164
Buckens et al. 2020

Ephrin receptors can act as either tumor promoters or suppressors, making the clinical application of inhibitors difficult. Drugs targeting Eph receptors, such as JI-101, XL647, and KB004, have been developed
Werner et al. 2015 Invest New Drugs 33(6): 1217-1224
Swords et …

References (Sources)

A pilot study of JI-101, an inhibitor of VEGFR-2, PDGFR- β , and EphB4 receptors, in combination with everolimus and as a single agent in an ovarian cancer expansion cohort
Werner et al. 2015 Invest New Drugs 33(6): 1217-1224
A role of the SAM domain in EphA2 receptor activation
Shi et al. 2017 Sci Rep. 7(1): 45084
Crystal structure of an Eph receptor-ephrin complex
Himanen et al. 2001 Nature 414(6866): 933-938
Eph receptors and ephrins as targets for cancer therapy
Xi et al. 2012 J Cell Mol Med. 16(12): 2894–2909
KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: results from a phase 1 study
Swords et al. 2016 Leuk Res. 50: 123-131
Multiple roles of EPH receptors and ephrins in neural development
Wilkinson 2001 Nat Rev Neurosci 2: 156-164
Review
Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation
Hamaoka et al. 2018 Biochemical and Biophysical Research Communications 499(4): 920-926

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Ephrin receptor - Wikipedia