EphA receptors

EphA receptors interact with their cognate ligands, A-type ephrins, with high affinity in the nanomolar range. This binding triggers various signaling cascades that regulate cell behavior.
Wilkinson 2001 Nat Rev Neurosci 2: 156-164

The EphA-ephrin-A interaction can activate the exchange factor Vav2, which in turn activates RhoA, a small GTPase involved in cytoskeletal reorganization
Batson et al. 2014 Biol Open 3(6): 453-62

Ephrin A ligands use a glycophosphatidylinositol anchor
Xi et al. 2012 J Cell Mol Med. 16(12): 2894–2909

EphrinA ligands bind to EphA receptors
Kania & Klein 2016 Nat Rev Mol Cell Biol. 17(4): 240-256

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