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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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NCT02341248 - Exclusive Enteral Nutrition (EEN) & Crohn’s Disease (CD) (pediatric)

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Background

During exclusive enteral nutrition in children with active Crohn's disease, there is a decrease in fecal calprotectin levels (2).

Study overview

It is a prospective, case-control clinical trial studying Exclusive Enteral Nutrition (EEN) in 22 included children (3 years to 17 years) with active Crohn’s Disease (CD) (pediatric) vs healthy children unrelated to Crohn's disease (1)

Primary outcome measures

Change in short chain fatty acid level following treatment, gut bacterial composition, mucosal bacterial composition

Results

After EEN treatment, 8 out of 11 patients (72%) showed a reduction in [fecal c…

References (Sources)

The reduction of faecal calprotectin during exclusive enteral nutrition is lost rapidly after food re-introduction
Logan et al. 2019 Aliment Pharmacol Ther 50: 664
Treatment of Active Crohn’s Disease With Exclusive Enteral Nutrition Diminishes the Immunostimulatory Potential of Fecal Microbial Products
Kerbiriou et al. 2024 Inflammatory Bowel Diseases 30(12): 2457-2466

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