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Isolithocholic acid (isoLCA), 3-oxolithocholic acid (3-oxoLCA) both target RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) and inhibit CD4+ Th17 cells function (anti-inflammatory effect)
see also:
RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) & T helper 17 cell (Th17)
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