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High Fusobacterium nucleatum levels are associated with shorter survival in colorectal cancer, especially in MSI-high contexts
Fusobacterium nucleatum is more abundant in MSI-high tumors, particularly hereditary MSI cancers (e.g., Lynch syndrome), compared to sporadic MSI or microsatellite-stable (MSS) cases
Fusobacterium nucleatum is linked to suppressed tumor-infiltrating lymphocytes (TILs) and poorer prognosis. Despite MSI-high tumors typically generating immunoge…