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Alterations in the activity of tryptophan 2,3-dioxygenase (TDO) can cause imbalances in serotonin and other neuroactive metabolites. These imbalances may contribute to motor, psychiatric, gastrointestinal, and other dysfunctions commonly observed in Morbus Parkinson / Parkinson's Disease (PD). Recent data from experimental models suggest that modulating Tryptophan 2,3-dioxygenase activity could have beneficial effects on Morbus Parkinson / Parkinson's Disease (PD) symptoms that are not addressed by traditional dopamine substitution therapies.
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Tryptophan 2,3 Dioxygenase (TDO)
Tryptophan 2,3 Dioxygenase (TDO) inhibitors