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Rare variants in HCAR1, HCAR2, and HCAR3 have been identified in breast cancer cases. Some variants are associated with breast cancer risk, highlighting the importance of these receptors in cancer development
GPR109a acts as a tumor suppressor in breast and colon cancers.
Its activation with butyrate induces apoptosis in breast and colon carcinoma cells, while its deletion increases tumor incidence in spontaneous [bre…