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Dendritic cells along with regulatory T cells play a crucial role in maintaining immune balance. If the function or number of these cells is disrupted, it can result in severe autoimmune conditions. In mice that inherently lack DCs, referred to as ΔDC, autoimmunity develops. This absence of DCs causes a change in the gene expression profile of peripheral Tregs, but not thymic Tregs, leading to an increase in the expression of inhibitory receptors. In…