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Lipids A, the lipophilic component of lipopolysaccharides, have been shown to induce regression in various tumor types in animal models. These compounds do not exert a direct cytotoxic effect; instead, they activate the immune system. This activation leads to the secretion of cytokines, the activation of inducible nitric oxide synthase, and the infiltration of immune cells into tumors.
OM-174 is an analogue of lipid A that acts on [Toll-like receptors 2](brain://q--cDtBHWE-tyfs2BBMXCQ/Tolll…