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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Lipid A

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Lipid A is the hydrophobic moiety of LPS that is composed of a glucosamine disaccharide which anchors LPS to the outer leaﬂet of the Gram-negative outer membrane.
Liu et al. 2024a Trends in Immunology 45(4): 274

Some bacteria have evolved strategies to modify their lipid A structure. Modifications in the lipid A structure can influence how it is recognized by the host immune receptor Toll-like receptor 4 (TLR4) and the subsequent immune responses.
Papadopoulos et al. 2021a Infect Immun. 89(2): e00335-20
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References (Sources)

Lipopolysaccharide delivery systems in innate immunity
Liu et al. 2024a Trends in Immunology 45(4): 274
Review
Microbial Lipid A Remodeling Controls Cross-Presentation Efficiency and CD8 T Cell Priming by Modulating Dendritic Cell Function
Papadopoulos et al. 2021a Infect Immun. 89(2): e00335-20

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