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Mitochondrial dysfunction has been associated with neurodegeneration in Morbus Parkinson / Parkinson's Disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an initiator, propagator, or bystander remains undetermined.
The discovery of the role of the Morbus Parkinson / Parkinson's Disease (PD) familial genes PTEN-induced putative kinase 1 (PINK1) and parkin (PRKN) in mediating mitochondrial degradation (mitophagy) reaffirmed the importance o…