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The term ‘colonization resistance’ describes the now widely recognized protection conferred by the gut microbiota (5).
The complex microbial community occupying the Intestine / Gastrointestinal Tract (Gut / GIT) plays a crucial role in preventing pathogen invasion through direct and indirect mechanisms like the barrier effect, referred to as colonization resistance (1, 3).
The microbiota prevents the colonization of harmful organisms that could cause or exacerbate disease through the production of toxins (e.g., bacteriocins) or detrimental metabolites or compete for limited nutrient sources (2, 3). Lachnospiraceae consume free sugars and contribute to colonization resistance (6).
By immune stimulation Candidatus savagella enhances immunity to intestinal pathogens (7). The beneficial effects of Bifidobacterium are partly due to its immunostimulatory properties. The high frequency of CpG motifs in the DNA of Bifidobacterium may play an essential role in it (8).
Colonization resistance provides broad protection from bacteria, viruses, and possibly other classes of pathogens (4).
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see also:
Biological effects / Functions & Gut microbiota
Defending & Pathogens / Pathobionts / Pathogenic Bacteria
Eubiosis / Homeostasis
Gram-positive Bacteria & Regenerating Islet-Derived Protein 3 Gamma / Regenerating Islet-Derived Protein III-Gamma (REG3G)
Salmonella enterica enterica serovar Typhimurium