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In Breast cancer / Mammacarcinoma (HER2+), the established “Chemotherapy (CT) + Tyrosine kinase inhibitors (TKIs)” combinations are mainly used in the advanced or metastatic setting rather than as core first-line therapy for all patients. The key regimens are Capecitabine + Trastuzumab + Tucatinib, lapatinib + capecitabine, neratinib + capecitabine, and in China pyrotinib + capecitabine.
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