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Trimethylamine-N-oxide (TMAO) is a metabolite produced by gut microbiota and is known to have a strong association with cardiovascular diseases (CVD), particularly by elevating the risk of developing atherosclerosis. At present, there are no approved pharmacological methods specifically aimed at reducing TMAO serum levels. Conventional treatments for atherosclerosis focus solely on addressing traditional risk factors, yet the cardiovascular risk (CVR) remains. Polyphenols have been shown in several studies to inhibi…