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The speculative mechanisms for the gut-microbiota-brain-cancer axis have been scrutinized in four sections: (i) through the Kynurenine pathway; (ii) through mediation of types 1 and 2 T helper cells and the subsequent modulation of microglia (independent of the Kynurenine pathway); (iii) myeloid-derived suppressor cells (MDSCs); and (iv) amino acid deprivation (i.e., [arginine](brain://v…