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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Butyrate / Butyric acid & Interleukin-12 (IL-12)

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Butyrate / Butyric acid directly enhanced cytotoxic CD8 +T cell response through ID2-dependent IL-12 signaling via its HDAC inhibitory activity, thus promoting the antitumor efﬁcacy of oxaliplatin and anti-PD-L1 therapy
He et al. 2021c Cell Metabolism 33: 988-1000

![Butyrate boosts the antitumor CD8+ T cells](.data/md-images/f1271c6f-d935-4d27-b95c-12686a0ab682.…

CX3CR1 identiﬁes PD-1 therapy-responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy
Yan et al. 2018 JCI Insight 3: e97828
Gut microbial metabolites facilitate anticancer therapy efﬁcacy by modulating cytotoxic CD8(+) T cell immunity
He et al. 2021c Cell Metabolism 33: 988-1000
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
Chang et al. 2014 Proc. Natl. Acad. Sci. U. S. A. 111: 2247–2252

7/1/2026