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Inosine, a metabolite generated by gut bacteria, plays a crucial role in restoring the function of antiviral T cells. It achieves this by modulating gene regulation, which in turn enhances the immune defenses in the lungs against respiratory viruses (1)
Gut microbiota metabolite inosine, e.g., produced by intestinal bacteria Bifidobacterium pseudolongum, significantly promotes the differentiation of Th1 cells in the presence of exogenous [IFN-gamma](brain://jJh19XffL…