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Chemotherapy (CT) is the primary treatment, especially for younger patients (4). Older AML patients have a poor prognosis, even with hypomethylating agents (5).
Many AML patients relapse after responding to induction chemotherapy (3). Relapsed and refractory Acute myeloid leukemia (AML) patients have a poor survival rate with traditional chemotherapies (1). And long-term survival in AML remains low despite treatment advances (2).
Leukemic stem cells (LSCs) are crucial in relapsed and refractory AML (2).
(1)
(2) Pabon et al. 2022 Expert Opinion on Ther…