NFKB Signal transduction / NFKB Signal transduction pathway

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NF-kB Pathway
The NFKB pathway regulates inflammatory gene expression via the RelA:p50 transcription factor. The classic "canonical" NF-κB complex is a heterodimer of p50 and RelA. While in an inactivated state, NFKB is located in the cytosol complexed with the inhibitory protein IκB alpha. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase (IKK). IKK, in turn, phosphorylates the [IκB alfa](brain:/…

References (Sources)

Gene Regulation
Jandhyala et al. 2012
Innate and adaptive effects of inflammasomes on T cell response
Dostert et al. 2013
Negative Regulatory NLRs Mitigate Inflammation via NF-κB Pathway Signaling in Inflammatory Bowel Disease
Morrison et al. 2023 Biomedical Journal 46(5): 100616
Review
NF-kappaB functions as a tumour promoter in inﬂammation-associated cancer
Pikarsky et al. 2004 Nature 431: 461–466
Oscillations in NF-kappaB signaling control the dynamics of gene expression
Nelson et al. 2004 Science 306: 704-708
The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inﬂammation Through Antagonizing NF-κB Signaling Pathway
Guo et al. 2015 Front Pharmacol 6: 287
Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB
Seldin et al. 2016 J Am Heart Assoc. 5: e002767

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