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Indoleamine 2,3-dioxygenase (IDO) is a key enzyme involved in tryptophan metabolism that plays a critical role in cancer by promoting immune tolerance and aiding tumor immune escape. It catalyzes the degradation of tryptophan to kynurenine in the tumor microenvironment. Tryptophan depletion and kynurenine accumulation suppress effector T-cell proliferation and stimulate the generation of […