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In general, this means reducing side effects and/or improving effectiveness. However, the strongest review-level evidence is for reducing radiation-induced diarrhea/bowel toxicity, not for improving tumor response itself
A systematic review and meta-analysis examined the effects of probiotic supplementation for prevention of radiation-induced diarrhea. This study included six randomized clinical trials (RCTs) conducted up to June 2012.
The analysis indicated an unclear risk due to incomplete outcome data and the absence of intention-to-treat analysis. Additionally, issues with blinding and randomization were noted in certain studies. The pooled results demonstrated heterogeneity, as evidence…