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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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PARPs (Poly(ADP-Ribose) Polymerases) Inhibitors & Preclinical/Clinical data

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Early clinical trials with PARPs (Poly(ADP-Ribose) Polymerases) Inhibitors showed clinical activity particularly in participants with BRCA associated cancers
Fong et al. 2009 N Engl J Med 361(2): 123-134
Sandhu et al. 2013 Lancet Oncol 14(9): 882-892
Kaufman et al. 2015a J Clin Oncol 33(3): 244-250
de Bono et al. 2017 Cancer Discov 7(6): 620-629

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References (Sources)

Inhibition of poly(adp-ribose) polymerase in tumors from BRCA mutation carriers
Fong et al. 2009a N Engl J Med 361(2): 123-134
Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation
Kaufman et al. 2015a J Clin Oncol 33(3): 244-250
Phase I, dose-escalation, two-part trial of the PARP inhibitor talazoparib in patients with advanced germline BRCA1/2 mutations and selected sporadic cancers
de Bono et al. 2017 Cancer Discov 7(6): 620-629
The PARP enzyme family and the hallmarks of cancer part 2: hallmarks related to cancer Host interactions
Demény & Virág 2021 Cancers (Basel) 13(9): 2057
Review
The poly(adp-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
Sandhu et al. 2013 Lancet Oncol 14(9): 882-892

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PARPs (Poly(ADP-Ribose) Polymerases) Inhibitors & Preclinical/Clinical data

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