Drug Discovery

Although the archetypal discovery process did not change markedly in the first seven decades of the twentieth century of the industry, the past fifty years have seen two successive waves of transformative innovation in the development of drug molecules: the rise of ‘rational drug discovery’ methodology in the 1970s, followed by the invention of recombinant protein-based therapeutic agents in the 1980s. An incipient fourth wave is the advent of multispecific drugs.
Deshaies 2020

The basis of rational drug discovery referred to here as ‘one target:one drug’ (1T1D)—is to start with a target and identify a molecule that binds the target, such that it increases or decreases its function.
Deshaies 2020

An early example was Squibb’s development of captopril as an angiotensin-converting enzyme inhibitor for hyperte…