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The gut microbiota has become a promising new therapeutic target aimed at enhancing the effectiveness of immune checkpoint blockade. Enterococcus gallinarum MRx0518 is an innovative, gut microbiome-derived, oral live biotherapeutic. It is specifically designed to trigger a wide-ranging immunostimulatory response, which helps to re-engage the activity of PD-1 inhibitors. In preclinical studies, MRx0518 demonstrated a reduction in tumor growth across models of kidney, lung, and breast cancer. The treatment led to an increase in the infiltration of CD4 and C…