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IL-10 signalling is crucial. It modulates mucosal inflammation in the intestine. Deleting IL-10 or its receptor (IL-10R) causes severe inflammatory bowel disease (IBD). This occurs in both mice and humans (4, 5, 6, 7).
IL-10 is an anti-inflammatory cytokine. It limits immune activation. It affects both innate and adaptive immune cells (2). IL-10-producing CD4 cells suppress colitis (3).
In…