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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)

Non-Alcoholic Fatty Liver Disease (NAFLD) / Metabolic dysfunction-associated fatty liver disease (MAFLD) & Drugs/Treatments

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Clinical Outcomes in NAFLD Trials

The primary clinical outcomes observed in trials for Non-Alcoholic Fatty Liver Disease (NAFLD) / Metabolic dysfunction-associated fatty liver disease (MAFLD) include:

Hepatic fat content

Improvement in hepatic histology (such as in Non-Alcoholic Steatohepatitis (NASH) or fibrosis)

Adverse events (safety)

Goals and Strategies in NAFLD Treatment

The ultimate goal in treating NAFLD is to prevent mortality and progression to cirrhosis…

References (Sources)

Current insights in molecular characterization of non-alcoholic fatty liver disease and treatment
Che et al. 2022f Front Endocrinol (Lausanne) 13:1002916
Review
NASH and NAFLD: emerging drugs, therapeutic targets and translational and clinical challenges
Alkhouri 2020
Non-alcoholic fatty liver disease: the diagnosis and management
Abd El-Kader & El-Den Ashmawy 2015 World J Hepatol 7: 846-58
Review
Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease
Sanyal et al. 2021 N Engl J Med 385:1559-1569
Review article: can bugs be drugs? The potential of probiotics and prebiotics as treatment for non-alcoholic fatty liver disease
Koopman et al. 2019 Aliment Pharmacol Ther. 50(6): 628-639
Review
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
Chalasani et al. 2018 Hepatology 67: 328-357
Review
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review
Singh et al. 2017a World J Gastroenterol. 23(36): 6549-6570

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10/17/2026

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