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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Probiotics (living agents) & Anxiety / Anxiety Disorder

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Contents

The clinical evidence is mixed and generally not strong enough to support probiotics as an established treatment for anxiety disorders at this point.
de Souza et al. 2023 PharmaNutrition 26: 100362
Asad et al. 2025 Nutr Rev 83(7): e1504-e1520

Preclinical data

Escherichia coli Nissle 1917 / E. coli Nissle 1917 supplementation persistently ameliorated anxiety responses in mice with streptomycin-induced dysbiosis.
Park et al. 2021a Nutrients 13: 811

Lacticaseibacillus rhamnosus B-8238 + [Lactiplantibacillus plantarum 8PA3](brain://UWpBIiCUzUmxrPwXw25jPQ/L…

References (Sources)

Effects of Microbiota Imbalance in Anxiety and Eating Disorders: Probiotics as Novel Therapeutic Approaches
Navarro-Tapia et al. 2021
Review
Efficacy and safety of probiotics in the treatment of depression and anxiety: An umbrella review of systematic reviews of randomized clinical trials
de Souza et al. 2023 PharmaNutrition 26: 100362
Meta-Analysis
Review
Impact of consuming a milk drink containing a probiotic on mood and cognition
Benton et al. 2007 Eur. J. Clin. Nutr. 61(3): 355-361
Lactiplantibacillus plantarum Lp815 decreases anxiety in people with mild to moderate anxiety: a direct-to-consumer, randomised, double-blind, placebo-controlled study
Grant et al. 2025 Benef Microbes Apr 24: 1-12 doi: 10.1163/18762891-bja00073
Probiotic Escherichia coli Ameliorates Antibiotic-Associated Anxiety Responses in Mice
Park et al. 2021a Nutrients 13: 811
Probiotics as a treatment for prenatal maternal anxiety and depression: A double-blind randomized pilot trial
Browne et al. 2021a Sci. Rep. 211: 3051
Protective Effects of Probiotics on Cognitive and Motor Functions, Anxiety Level, Visceral Sensitivity, Oxidative Stress and Microbiota in Mice with Antibiotic-Induced Dysbiosis
Arslanova et al. 2021 Life 11: 764

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7/1/2026

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