G-Protein Coupled Receptor 120 (GPR120)

G-Protein Coupled Receptor 120 (GPR120) is a G-protein coupled receptor that is activated by medium-chain and Long-chain fatty acids (LCFAs). The receptor can be activated by both saturated (e.g., palmitic acid) and unsaturated (e.g., docosahexaenoic acid) long-chain fatty
Suckow et al. 2014 J Biol Chem 289(22): 15751-63
Wang et al. 2022 Molecules 27(24): 9018

G-Protein Coupled Receptor 120 (GPR120) activation has been shown to improve Glucose tolerance / Oral glucose tolerance test (OGTT) and insulin sensitivity
Cox et al. 2016 ACS Med Chem Lett 8(1): 49-54
Wang et al. 2022 Molecules 27(24): 9018

It is highly expressed in adipose tissue, colon, and pituitary, with more modest expression levels in Pancreatic islets. It potentiates glucagon secretion from pancreatic islets, which is significantly reduced in GPR120 knockout mice
Suckow et al. 2014 J Biol Chem 289(22): 15751-63

GPR120, an omega-3 fatty acid-activated receptor, is additionally expressed in bone marrow-derived dendritic cells and macrophages
Im 2016 European Journal of Pharmacology 785: 36-43
Liang et al. 2019 Journal of the National Cancer Institute 111(1): 52-59

It is, among other things, a luminal receptor on I cells, and K cell

see also:
Body fat / Adipose Tissue & Macrophages (CD68s)
Cancer / Tumors & Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs)
G-Protein Coupled Receptor 120 (GPR120) agonists
G-Protein Coupled Receptor 120 (GPR120) agonists & Type 2 Diabetes (T2D)
Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs)
Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) & Prostate cancer