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In recent studies, the gut microbiota has been linked to how humans respond to immune checkpoint inhibitors (ICIs), and it has been shown to play a causal role in ICI responsiveness in animal models. Two human trials have recently revealed that fecal microbiota transplant (FMT) from individuals who respond well to ICIs can restore ICI responses in cases of refractory melanoma. However, FMT presents specific challenges when it comes to scaling its use (1).
NCT03686202 - MET4-IO - Immune Checkpoint Inhibitors (ICIs) + Mi…