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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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NKG2A receptor

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The NKG2A receptor is an inhibitory receptor expressed on natural killer (NK) cells

NKG2A dimerizes with CD94 (killer cell lectin-like receptor subfamily D, member 1 (KLRD1)) to make the inhibitory receptor CD94/NKG2
Huang et al. 2021 J Am Soc Mass Spectrom. 32(7): 1567-1574

This complex recognizes and binds to HLA-E in humans (or Qa-1b in mice), which are non-classical MHC class I molecules
Melero et al. 2023 EMBO Mol Med. 15(11): e17804

When NKG2A/CD94 binds to HLA-E, it triggers an inhibitory signal that suppresses the cytotoxic activity of these immune cells
Gong et al. 2023 Hemasphere 7(Suppl): e4346010

References (Sources)

Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies
Huang et al. 2021 J Am Soc Mass Spectrom. 32(7): 1567-1574
Intratumoral co-injection of NK cells and NKG2A-neutralizing monoclonal antibodies
Melero et al. 2023 EMBO Mol Med. 15(11): e17804
P1368: NKG2A DELETION IN HUMAN NATURAL KILLER CELLS ENHANCES ANTI-TUMOR RESPONSES AND PROMOTES TUMOR INFILTRATION
Gong et al. 2023 Hemasphere 7(Suppl): e4346010

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