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Regulatory T cells have a critical role in the maintenance of immune homeostasis in mice and man. However, despite their role in maintaining host integrity, their function is known to be hijacked in the context of cancer. The murine and human tumour microenvironment actively recruits regulatory T cells bearing features of activation such as upregulation of the high affinity IL2Ra (CD25) and the immune-regulatory receptor CTLA-4. In mice, anti-CTLA-4 antibodies are able to promote depletion of Tregs and enhanced tumour control whilst in humans this remains less clear. That said, in human cancers, the number of tumour infiltrating regulatory T cells and their spatial distribution with regards to effector T cells has been negatively associated to patient outcomes, underscoring their negative role in anti-tumour …