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Myocarditis is most commonly caused by viral infections in the northern hemisphere and protozoan infections in the southern hemisphere (2)
Epelman 2019
In addition to infections, rare inflammatory cardiomyopathies and chemotherapeutic agents with a direct cardiotoxic or immunomodulating effect can trigger myocarditis (3, 4). Vice versa myocarditis can progress into inflammatory cardiomyopathy due to the chronic activation of myosin heavy chain 6-specific T helper (TH) 1 and TH 17 cells. Despite this understanding, the mechanisms that drive the cardiotoxic programming of heart-specific T cells have remained unclear.
Epelman 2019
Using a mouse model of spontaneous [autoimmune myocarditis](brain://eVpjSQG-qEue-rwSWNh0zg/AutoimmuneMyocarditis…