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Cancer Immunotherapy / Immuno-Oncology have failed to demonstrate significant clinical benefit in patients with glioblastoma.
Obstacles to success include the heterogeneous tumor microenvironment (TME), the immune-privileged intracranial space, the blood–brain barrier (BBB) and local and systemic immunosuppressions.
see also:
[Cancer Immunotherapy / Immuno-Oncology & Brain Tumors](brain://YIRJnGziCkOPsyGS5_obUw/CancerImmunotherap…