Engineered Live Biotherapeutic Products (LBPs) (eLBPs / synthetic biology LBPs)

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What are Engineered Live Biotherapeutic Products (LBPs) (eLBPs / synthetic biology LBPs)?

Engineered live biotherapeutic products (rLBPs) are living microorganisms genetically or heritably modified to perform a defined therapeutic function in patients. They are distinct from Traditional Probiotics, donor-derived microbiota products, vaccines, living diagnostics, environmental systems, and systemically administered oncolytic bacteria (1).

Target Product Profiles…

References (Sources)

Advances in bacterial cancer therapies using synthetic biology
Chien et al. 2017 Curr Opin Syst Biol 5: 1-8
Advances in biocontainment strategies of engineered microbes for use in humans
Fuerte-Stone & Mimee 2026 Current Opinion in Microbiology 91: 102727
Advances in engineered bacteria vaccines for enhancing anti-cancer immunity
Liu et al. 2025 Microbiome Res Rep 4(1): 14
Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes
Russell et al. 2022 Cell 185: 3263-3277
Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis
Zhao et al. 2022 J Mater Chem B 10: 4002-4011
Research and application of intelligent diagnosis and treatment engineering bacteria
Zhao et al. 2024 Front Bioeng Biotechnol 12: 1524376
Review
Tumour-targeting bacteria engineered to ﬁght cancer
Zhou et al. 2018 Nat Rev Cancer 18: 727-743
Review

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11/5/2026

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