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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Entrectinib

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Entrectinib is a highly effective inhibitor of tropomyosin receptor kinase (TRK) A, B, and C. It has demonstrated significant anti-tumor activity against NTRK gene fusion-positive solid tumors. Notably, it exhibits central nervous system (CNS) activity, attributed to its capability to cross the blood-brain barrier.
Doebele et al. 2020 Lancet Oncology 21: 271-282

Entrectinib is a ROS1 inhibitor that has been designed to effectively penetrate and remain in the CNS
Drilon et al. 2020
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References (Sources)

Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials
Doebele et al. 2020 Lancet Oncology 21: 271-282
Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1–2 trials
Drilon et al. 2020

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7/1/2026

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