NCT03561532 - Fecal Microbiota Transplantation (FMT) & Ulcerative Colitis (UC)

Background:

Knowledge regarding Fecal Microbiota Transplantation (FMT) for quiescent Ulcerative Colitis (UC) is scarce (1).

Study overview:

It is a randomized, double-blind treatment trial (Parallel Assignment) to evaluate Fecal Microbiota Transplantation (FMT) (fecal suspension of a healthy donor) or placebo (fecal suspension made of patients own feces) in 48 randomized patients with quiescent Ulcerative Colitis (UC) (1).

Primary outcome measures:

Maintenance of remission of ulcerative colitis

Results:

In the study, 13 out of 24 patients (54%) who received FMT reached the main goal, while 10 out of 24 patients (41%) in the placebo group did the same. This difference wasn't statistically significant (P = 0.660) (1).

Conclusion:

After 12 months, there was no difference in the number of relapses between the groups in the study. So, our findings suggest that using a single dose of FMT isn't effective for keeping UC in remission (1).

References:

(1) Lahtinen et al. 2023 World J Gastroenterol. 29(17): 2666-2678