Metabolic activities / Metabolism & Sulfoquinovose

Human and Mouse Sulfoquinovose Metabolism Compared

Human intestinal cells in vitro did not degrade Sulfoquinovose, indicating that humans do not directly metabolize it. The notes describe a distinct set of microbial degraders in humans and mice.

• In humans, Agathobacter rectalis can break down SQ to 2,3-dihydroxy-1-propanesulfonate (DHPS).


• In mice, Escherichia coli and Enterocloster clostridioformis are noted as key SQ degraders. A mouse-derived E. clostridioformis strain converted SQ only as far as DHPS (1).

Gut Microbes and Sulfoquinovose Degradation…