Loading…
Please register to continue your trial period!
meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Murepavadin is a novel, cyclic antibacterial peptide (also referred to as a peptidomimetic) that specifically targets Pseudomonas aeruginosa, especially in individuals with cystic fibrosis or ventilator-associated pneumonia. Its mechanism of action is unique: murepavadin selectively binds to the outer-membrane lipopolysaccharide transport protein LptD in P. aeruginosa, blocking the insertion of lipopolysaccharide (LPS) into the outer membrane. This disrupts membrane integrity, increases permeability, and ultimately leads to bacterial dea…