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Immune Checkpoint inhibitors (ICIs) + Tyrosine Kinase Inhibitors (TKIs) showed superior progression-free survival time and tumor response rate over TKIs alone as second-line treatment in patients with metastatic Renal cell carcinoma (RCC). However, future randomized prospective trials are necessary to validate these preliminary findings.
We conducted a Meta-analysis by gathering all relevant randomized clinical trials from sources such as the Cochrane Library, PubMed/Med, and EMBASE. Ultimately, we included three Phase III randomized clinical trials combining [Immune Check…