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At least 20% of B cells in the periphery express an antigen receptor with a degree of self-reactivity
If activated, these autoreactive B cells pose a risk as they can contribute to the development of autoimmune diseases
Both B cell-intrinsic and extrinsic tolerance mechanisms are in place in healthy individuals to prevent their activation
B-cells play a crucial role in autoimmunity as they differentiate into plasmocytes, which produce pathogenic auto-antibodies.
Bohelay et a…