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Monoclonal antibody-based therapies have failed at least in part due to their inability to access the intracranial compartment.
Recently, results of interventional clinical trials investigated the role of ICIs in patients with glioblastoma. Results of these studies suggested that only a small percentage of these patients could benefit from these agents.
Research of predictive markers assumes a critical importance to adequately select patients likely to benefit from ICIs.
see also:
Biomarker & Glioblastoma / Glioblastoma Multiforme
[Ipilimumab + Nivolumab & Glio…