Gut microbiota & Non-Alcoholic Fatty Liver Disease (NAFLD) / Metabolic dysfunction-associated fatty liver disease (MAFLD)

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How Does Gut Dysbiosis Affect MASLD Progression?

Gut microbial alterations can weaken the intestinal barrier and increase the movement of harmful substances from the gut to the liver. Dysbiosis may also disturb bile acid metabolism and change the production of short-chain fatty acids and tryptophan metabolites. These microbiome-related changes can promote [liver inflammation](brain://ap…

References (Sources)

Gut microbiome features and metabolites in non-alcoholic fatty liver disease among community-dwelling middle-aged and older adults
Zeng et al. 2024 BMC Med 22(1): 104
Gut microbiome in non-alcoholic fatty liver disease
Mpountouridis et al. 2025 Front Gastroenterol 3: 1534431
Review
Gut microbiota heterogeneity in non-alcoholic fatty liver disease: a narrative review of drivers, mechanisms, and clinical relevance
Guo et al. 2025 Front Microbiol 16: 1645298
Review
MAFLD under the lens: the role of gut microbiota
Sousa & Machado 2022 Metab Target Organ Damage 2:14
Review
Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies
Jayachandran & Qu 2023 Rev Endocr Metab Disord 24: 1189-1204
Review
Role of Gut-Liver Axis in Non-Alcoholic Fatty Liver Disease
Yaghmaei et al. 2025 Iran Biomed J 29(1 & 2): 1-8
Review
The Role of the Microbiome in NAFLD and NASH
Kolodziejczyk et al. 2019a EMBO Mol Med 11: e9302
Review

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