Less functional reliance on PI3K Signal transduction pathway and MAPK / ERK Pathway in Tregs compared with conventional CD4+ and CD8+ lymphocytes
Zwang et al. 2016

Regulatory T Cells (Tregs) exert their suppressive functions by secreting Interleukin-10 (IL-10), [Transforming growth factor beta (TGF-beta)](brain://0HQPXyRXdkGdJCNrmGbU…

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4 + T cell subsets
Michalek et al. 2011 J Immunol 186: 3299-3303
DC activated via dectin-1 convert Treg into IL-17 producers
Osorio et al., 2008
Extrathymically generated Treg cells control mucosal Th2 inflammation.
Josefowicz et al. 2012
FOXP3 + regulatory T cells in the human immune system
Sakaguchi et al. 2010 Nature 10: 490
Review
Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
Miyara et al. 2009 Immunity 30(6): 899- 911
Molecular and Cellular Characterization of Human CD8 T Suppressor Cells
Xu et al., 2016
Regulatory T cells and immune tolerance
Sakaguchi et al. 2008 Cell 133: 175
Review

10/17/2026

Regulatory T Cells (Tregs)

Welcome to meRfi Microbiome!