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Psoriatic arthritis (PsA) is a heterogeneous chronic rheumatic disorder with numerous phenotypic facets. A better in deep understanding of the pathophysiologic mechanisms leading to psoriasis and PsA has contributed to the introduction of novel therapeutic agents. IL-17 is at the heart and a critical factor in the onset of Psoriatic arthritis (PsA). Ixekizumab, a high-affinity monoclonal antibody against IL-17 A, has been approved by the US FDA in March 2016 for baseline psoriasis and Dec 2017 for PsA; [by the EMA in April 2016 and January 2018, respectively](brain://PjIIt-173Eyjx8ReNCIcNQ/ByTheEmaInApril2016AndJanuary201…