Autoimmune Diseases & T helper 17 cell (Th17)

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Th17 cells are key players in autoimmune disease
such as multiple sclerosis, psoriasis, autoimmune uveitis, juvenile diabetes, rheumatoid arthritis, and Crohn's disease.

Bacterial activation of T helper 17 cell (Th17) cells exacerbates mouse models of autoimmunity
Alexander et al. 2022 Cell Host & Microbe 30: 17-30

T helper 17 cell (Th17)-driven diseases are Rheumatoid Arthritis (RA) and Inflammatory Bowel Disease (IBD)
Alexander et al. 2022 Cell Host & Microbe 30: 17-30

The Ahr links Th17-cell-mediated autoimmunity to environmental toxins
Veldhoen et al. 2008 Nature 453(7191): 106-942

References (Sources)

Gut microorganisms act together to exacerbate inflammation in spinal cords
Miyauchi et al. 2020
Human gut bacterial metabolism drives Th17 activation and colitis
Alexander et al. 2022 Cell Host & Microbe 30: 17-30
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inﬂammation
Kebir et al. 2007 Nat. Med. 13: 1173–1175
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen et al. 2008 Nature 453(7191): 106-942

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Autoimmune Diseases & T helper 17 cell (Th17)

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