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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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CD335 (NKp46)

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CD335 (NKp46) is a 46-kDa glycoprotein belonging to the Immunoglobulin superfamily (IgSF) in both humans and mice
Moretta et al. 2006 Semin Immunol 18: 151-158

It is expressed by resting and activated NK cells, Group 1 ILCs (ILC1), a small population of T lymphocytes, and a subset of Group 3 ILCs (ILC3) (Natural Cytotoxicity Receptor Positive (NCR+) Group 3 ILCs (ILC3)) in mucosa.
Sivori et al.1997 J Exp Med 186: 1129-1136
Vivier et al. 2018

CD335 (NKp46) has been shown to be highly and speciﬁcally exp…

References (Sources)

Innate Lymphoid Cells: 10 Years On
Vivier et al. 2018
Review
Microbial Flora Drives IL-22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense
Satoh-Takayama et al. 2008 Immunity 29: 958
Multifunctional natural killer cell engagers targeting NKp46 trigger protective tumor immunity
Gauthier et al. 2019 Cell 177: 1701-1713
NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells
Sivori et al. 1999 Eur J Immunol 29: 1656-1666
P46, a Novel Natural Killer Cell-speciﬁc Surface Molecule that Mediates Cell Activation
Sivori et al.1997 J Exp Med 186: 1129-1136
Surface NK receptors and their ligands on tumor cells
Moretta et al. 2006 Semin Immunol 18: 151-158
Review
The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity
Biassoni et al. 1999 Eur J Immunol 29: 1014-1020

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NCR1 - Wikipedia