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Extracellular Amyloid-beta (Aß, Abeta) / Amyloid Plaques and intracellular neurofibrillary tangles are the main pathological hallmarks of the disease (9, 16).
The disease begins about 10–20 years earlier than symptoms and develops first asymptomatically through a long preclinical stage (10). The main clinical hallmarks of the disease (e.g., beta-amyloid plaques and neurofibrillary tangles) begin during preclinical AD, when cognitive deficits are not yet apparent (29).
Genetics, environment, and lifestyle are important risk factors for [Alzheimer…