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Enterocytes and other intestinal epithelial cells (IECs) form one of the body’s largest exposed surfaces. They integrate signals from the gut microenvironment with physiological information from the immune, cardiovascular, and nervous systems. The epithelium functions as an interface between the gut microbiome and the mucosal immune system and operates together with immune cells and the mesenchyme as a functional triad (7, 9, 14, 15)