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Binding of antibody to an antigen expressed on the tumor cell can cause receptor antagonist activity, leading to cell death. Antibody binding may also prevent downstream signaling critical for cell proliferation. The former mechanism has been observed for the anti-CD20 antibody rituximab, which inhibits the p38 MAPK/STAT3/NFκB/SP1/Bcl-2 pathway, the Src/Raf 1/MEK1/2/ ERK1/2/AP-1/Bcl-xL pathway, the NF-κB/Bcl-xL pathway, the AKT/Bcl-xL pathway and also causes re-distribution of CD20 in lipid rafts, all of which lead to eithe…